Table 3: Effects of early life seizures on receptors and currents in rats.

Seizure model Age Region Effects on GABAA receptors Ref. Ictal changes In vivo SE (Lithium-pilocarpine; continuous hippocampal stimulation) PN30 Hippocampus Reduced surface expression of β2/3, γ2 subunits but not of δ. [139] In vivo SE (lithium-pilocarpine) 4–7 week old Hippocampus Internalization of β2/3, γ2 subunits; reduced mIPSCs [140] After seizures Recurrent flurothyl seizures PN1-5 Hippocampus, somatosensory cortex Decreased amplitude of GABAergic IPSCs [141, 142] Flurothyl seizures PN6 or PN6-10 Hippocampus Decreased numbers of α1-ir neurons [143] Kainic acid SE PN9 Hippocampus At 3 weeks postictally: α1, α4, γ2 decrease; α2, α3 increase; α5 increase (CA3 only); β3 increase compared to controls [144] Lithium-pilocarpine PN10 Hippocampus (dentate gyrus) In adulthood: increased α1 expression, larger GABA current, enhanced zolpidem sensitivity [145] Lithium-pilocarpine SE PN20 Hippocampus Decreased α1 and increased α4 expression in the hippocampus of epileptic versus non-epileptic rats [146]