Table 3: Effects of early life seizures on 𝐺 𝐴 𝐡 𝐴 𝐴 receptors and currents in rats.

Seizure modelAgeRegionEffects on GABAA receptorsRef.

Ictal changes

In vivo SE (Lithium-pilocarpine; continuous hippocampal stimulation)PN30HippocampusReduced surface expression of β2/3, γ2 subunits but not of δ.[139]
In vivo SE (lithium-pilocarpine)4–7 week oldHippocampusInternalization of β2/3, γ2 subunits; reduced mIPSCs [140]

After seizures

Recurrent flurothyl seizuresPN1-5Hippocampus, somatosensory cortexDecreased amplitude of GABAergic IPSCs [141, 142]
Flurothyl seizuresPN6 or PN6-10HippocampusDecreased numbers of α1-ir neurons [143]
Kainic acid SEPN9HippocampusAt 3 weeks postictally: α1,
α4, γ2 decrease;
α2, α3 increase;
α5 increase (CA3 only);
β3 increase compared to controls
Lithium-pilocarpinePN10Hippocampus (dentate gyrus)In adulthood: increased α1 expression, larger GABA current, enhanced zolpidem sensitivity [145]
Lithium-pilocarpine SEPN20HippocampusDecreased α1 and increased α4 expression in the hippocampus of epileptic versus non-epileptic rats[146]