Findings References Humans GAD67
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GAD67 in prefrontal cortexVolk et al. [109 ] Akbarian et al. [110 ] Preserved # number of PV cells, cortex Woo et al. [111 ] Hashimoto et al. [112 ]
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GAD67 level in PV cells, cortexHashimoto et al. [112 ] Association with polymorphisms in GAD67 promoter Addington et al. [113 ] Chandelier Decrease in chandelier cells cartridges (GAT1+) in prefrontal cortex Woo et al. [114 ] Volk et al. [115 ] SST
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levels of SST in microarray analysis and
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number of SST cells, prefrontal cortexHashimoto et al. [116 ] NPY/CCK
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levels of NPY and CCK in microarray analysisHashimoto et al. [116 ] NRG1 Susceptibility locus in NRG1 Stefansson et al. [117 , 118 ] Zhang et al. [119 ] Yang et al. [120 ] ERB4 Susceptibility locus in ERB4 Silberberg et al. [121 ] BDNF/Trkb Downregulation of BDNF in prefrontal cortex Weickert et al. [122 ] Wong et al. [123 ] Downregulation of BDNF and Trkb in prefrontal cortex Takahashi et al. [124 ] PSA/NCAM
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PSA-NCAM complexes in hippocampusBarbeau et al. [125 ] Gamma Gamma oscillations are triggered by working memory tasks + selective attention Tallon-Baudry et al. [79 ] Howard et al. [81 ] Decreased power of cortical gamma oscillations and phase locking to memory task Spencer et al. [82 , 84 ] Cho et al. [85 ] Mice Erb4 Selective interneuron loss of Erb4 : “schizophrenia-like behaviors” Wen et al. [126 ] Erb4/Nrg1 Erb4 in PV cells is required for Nrg1-dependant regulation of LTP (hippocampus) Chen et al. [127 ] NR1 Selective loss of the NMDAr NR1 subunit in PV cells: decreased excitatory input to PV cells results in “schizophrenia-like behaviors” and
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expression of PV and GAD67 Belforte et al. [128 ] BDNF BDNF regulates activity-dependant maturation of PV cells Bdnf−/− and Trkb−/− :
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synaptic GAD67 and GABA and behavioral anomalies Huang et al. [129 ] Cotrufo et al. [130 ] Hashimoto et al. [131 ] PSA/NCAM Activity-mediated expression of PSA regulates PV cells maturation and visual plasticity Di Cristo et al. [132 ] Gamma Gamma oscillations are triggered by stimulating PV cells: enhanced performance Cardin et al. [77 ] Sohal et al. [83 ] Gamma oscillations depend on PV cells-mediated fast-synaptic inhibition Bartos et al. [72 ]
