Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders

<table>Sensory activity regulates perisomatic synapse maturation via multiple pathways. (a) Activity modulates GAD67 enzyme levels thereby ensuring normal GABA signaling for the appropriate downstream signaling events required for perisomatic synapse development. (b) Experience is also critical for removal of the PSA moiety from NCAM, allowing onset of perisomatic innervation at the right time.</table>

Neural Plasticity

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Figure 1: Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders 

Figure 1 | Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders 