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Neural Plasticity
Volume 2011 (2011), Article ID 875307, 6 pages
http://dx.doi.org/10.1155/2011/875307
Research Article

Correlations between Hippocampal Neurogenesis and Metabolic Indices in Adult Nonhuman Primates

1Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
2Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, NY, USA
3Department of Psychiatry, College of Physicians and Surgeons, Unit # 126, 1051 Riverside Drive, New York, NY 10032, USA
4Department of Psychiatry, State University of New York Downstate Medical Center, Nonhuman Primate Facility, Department of Psychiatry, Brooklyn, NY, USA
5Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA

Received 19 November 2010; Revised 6 April 2011; Accepted 10 May 2011

Academic Editor: Anthony Hannan

Copyright © 2011 Tarique D. Perera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Increased neurogenesis in feeding centers of the murine hypothalamus is associated with weight loss in diet-induced obese rodents (Kokoeva et al., 2005 and Matrisciano et al., 2010), but this relationship has not been examined in other species. Postmortem hippocampal neurogenesis rates and premortem metabolic parameters were statistically analyzed in 8 chow-fed colony-reared adult bonnet macaques. Dentate gyrus neurogenesis, reflected by the immature neuronal marker, doublecortin (DCX), and expression of the antiapoptotic gene factor, B-cell lymphoma 2 (BCL-2), but not the precursor proliferation mitotic marker, Ki67, was inversely correlated with body weight and crown-rump length. DCX and BCL-2 each correlated positively with blood glucose level and lipid ratio (total cholesterol/high-density lipoprotein). This study demonstrates that markers of dentate gyrus neuroplasticity correlate with metabolic parameters in primates.