Matrix Metalloproteinases and Minocycline: Therapeutic Avenues for Fragile X Syndrome

Figure 1

Schematic of potential interaction mechanisms between FMRP and MMPs. FMRP may more directly regulate MMPs at the level of transcript stability, translation, or protein function. FMRP may more indirectly convergently interact with MMPs in the regulation of extracellular matrix (ECM) components and their receptors, via the endogenous TIMP regulatory mechanism, or via glutamate receptor (GluR) signaling.