| Brain structures | Models | Age | Up | Down | Method | Additional comment | Target | Rescue | References |
| E11–E13 telencephalon, mesencephalon + diencephalon | TgYAC152F7 | E11.5, E12.5, E13.5 | Dyrk1a | | Q, M | Dysregulation of the Rest pathway | | | [37] |
| Embryonic, brain hemispheres, cerebellum | Ts1Cje; TgPCP4 | E11.5, E14.5, 4 m | Pcp4 | | Q | | | | [38] |
| Embryonic total | Tc1 | E14.5 | –- | | R | Expression human genes | | | [32] |
| Embryonic | mBACTgDyrk1a | E14.5 | Dyrk1A | | Q | | | | [25] |
| Total brain | Ts1Cje | birth | mean: 1.435 | | M | | | | [39] |
| Cerebellum | Ts1Cje | birth | Ptch, Shh | | M | | | | [26] |
| Cortex, brain | Ts65Dn | 8 d | Vip, Vipr1 | | Q | | | | [40] |
| Total brain | Ts65Dn | 1 m | 62% of 3-copy genes | | Q | | | | [18] |
| Hippocampus, frontal cortex, substantia nigra | Ts65Dn | 78–92 d | Kcnj6 | | Q | | | | [41] |
| Hippocampus | TgYAC152F7 | 3 m | Dyrk1a | Bdnf, Trkb | Q | | Dyrk1a | Bdnf, Trkb | [42] |
| Hippocampus | TS65Dn | 3 m | Gart, Ifnar2, Kcnj6, Itsn1, Hcls, Sod1 | | M | | Gabra5 | Bdnf | [43] |
| Cerebellum | Ts65Dn | 3-4 m | range (0.84–2.93); mean 1.45 | | M | | | | [44] |
| Cortex, midbrain, cerebellum | Ts65Dn | 4 m | mean: 1.63, 1.3, 1.37 | | C, M | | | | [17] |
| Forebrain | Ts65Dn | 4 m | App, Sod1, ApoE | | N | | | | [45] |
| Hippocampus (rescue), prefrontal cortex | Ts65Dn | 5-6 m | mir155, mir802, Mef2c | Creb1, Mecp2 | Q | | mir-155, mir-802 | Mecp2, Mef2c, Creb1 | [46] |
| Brain hemispheres | Ts65Dn | 4 to 12 m | App, Sod1, Dyrk1a | | Q | increase with age | | | [21] |
| Brain | Ts65Dn | 6-7 m | | Gfap | Q | | | | [47] |
| Hippocampus, cortex, raphe nuclei | Ts65Dn | 9.5 m | Vip, Vipr1 | | Q | | | | [48] |
| Hippocampus | Ts65Dn | 10 m | | Bdnf | Q | | Nmdar | Bdnf | [49] |
| Total brain | Ts65Dn | 11 m | 47% of 3-copy genes | | Q | | | | [18] |
| Hippocampal CA1 | Ts65Dn (m + f) | 12–24 m | Htr2c | Cdk5, Ntf3 | Q | | | | [50] |
| Medial septum, hippocampus | Ts65Dn | 18 m | App | | Q | | | | [51] |
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