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Neural Plasticity
Volume 2012 (2012), Article ID 197264, 11 pages
http://dx.doi.org/10.1155/2012/197264
Research Article

Cross-Modal Recruitment of Primary Visual Cortex by Auditory Stimuli in the Nonhuman Primate Brain: A Molecular Mapping Study

1Department of Psychology, McGill University, Montreal, QC, Canada H3A 1B1
2School of Optometry, Université de Montréal, Montreal, QC, Canada H3T 1P1

Received 1 February 2012; Revised 17 April 2012; Accepted 7 May 2012

Academic Editor: Ron Kupers

Copyright © 2012 Priscilla Hirst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent studies suggest that exposure to only one component of audiovisual events can lead to cross-modal cortical activation. However, it is not certain whether such crossmodal recruitment can occur in the absence of explicit conditioning, semantic factors, or long-term associations. A recent study demonstrated that crossmodal cortical recruitment can occur even after a brief exposure to bimodal stimuli without semantic association. In addition, the authors showed that the primary visual cortex is under such crossmodal influence. In the present study, we used molecular activity mapping of the immediate early gene zif268. We found that animals, which had previously been exposed to a combination of auditory and visual stimuli, showed increased number of active neurons in the primary visual cortex when presented with sounds alone. As previously implied, this crossmodal activation appears to be the result of implicit associations of the two stimuli, likely driven by their spatiotemporal characteristics; it was observed after a relatively short period of exposure (~45 min) and lasted for a relatively long period after the initial exposure (~1 day). These results suggest that the previously reported findings may be directly rooted in the increased activity of the neurons occupying the primary visual cortex.