ZD7288 Enhances Long-Term Depression at Early Postnatal Medial Perforant Path-Granule Cell Synapses
Figure 2
ZD7288 has no effect on LFS-induced LTD in adult rats. (a) The time course of the fEPSP amplitude following LFS in adult rats (P30–60) shows LTD (closed symbols) as compared to time-control experiments without LFS (open symbols). Representative fEPSPs were taken at the beginning (indicated by “1”) and at the end (indicated by “2”) of the experiment. (b) Comparing the fEPSP amplitude time course following ZD7288 treatment (starting 10 min prior to LFS, indicated by a closed bar) between LFS-treated (closed symbols) and non-LFS-treated time-control experiments (open symbols) reveals a synaptic depression which was similar to that in non-ZD7288 conditions shown in (a). (c) Normalized time courses of fEPSP amplitudes in both conditions: without ZD7288 (open symbols) and ZD7288 before LFS (closed symbols). Note that similar levels of LFS-induced STD and LTD were obtained in both slices without ZD7288 and slices with ZD7288 before LFS. (d) The bar graph summarizes the STD and LTD levels in both ZD7288 and non-ZD7288 conditions. The number of slices is given in parentheses (number of LFS-treated slices/number of non-LFS-treated slices). (e) The bar graph summarizes the paired-pulse ratio of all experimental groups recorded at the beginning of each experiment, that is, before ZD7288 and/or LFS were applied to the slices. Note that the PPR was similar in all groups. All data are mean ± SEM.
