GluA1 Phosphorylation Alters Evoked Firing Pattern In Vivo

Figure 1

Schematic outline of the experiment. CA1 cells were excited by a small (a) or large (b) dose of excitatory compound (AMPA or NMDA). In a second set of experiments, AMPA receptor phosphorylation (GluA1 subunit), which might lead to increased AMPA receptor surface expression and subsequent rise in AMPA-evoked firing rate, was induced by an intraperitoneal tianeptine injection (c). Strong excitations triggered larger firing rates than weak excitations (d). Representative spike trains, superimposed spikes, and autocorrelograms of the same unit before (e) and 15 min after tianeptine injection (f). Red line marks the ejection event. Scale bars are 50 μV and 1 sec and 0.1 ms.