Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats

Table 1

Numerical density of dendritic spines in hippocampal CA1 pyramidal neurons of male rats 24 hours after the treatment with vehicle, raloxifene, or tamoxifen.

	Vehicle	Raloxifene	Tamoxifen
Total spines	161.0 ± 5.0	258.2 ± 3.0^a	255.0 ± 4.0^b
Thin	74.8 ± 2.8	89.6 ± 3.8^a	78.0 ± 3.6^c
Mushroom	50.4 ± 1.8	84.6 ± 3.2^a	92.8 ± 1.6^bc
Stubby	28.6 ± 1.4	65.8 ± 1.8^a	71.0 ± 2.2^b
Wide	6.2 ± 0.6	15.6 ± 1.0^a	11.8 ± 1.2^bc
Branched	0.4 ± 0.1	0.6 ± 0.2	0.6 ± 0.1
Double	0.1 ± 0.04	0.04 ± 0.04	0.4 ± 0.1

Data represent mean ± SEM of the number of dendritic spines per 100 μm dendritic segment from 6 animals in each experimental group. a-cSignificant differences, 𝑃<0.05; ^araloxifene versus Vehicle;  ^btamoxifen versus. Vehicle; ^ctamoxifen versus Raloxifene.