Spines, Plasticity, and Cognition in Alzheimer's Model Mice

Table 1

Progressive synaptic malfunction AD transgenic mice.

Model	Mutations	Age (months)	Basal synaptic transmission	Long-term potentiation	Paired-pulse facilitation
		2-3		Impaired [73]
Tg2576	APPswe	4–6	Impaired [74]	Normal [74]/impaired [73]
		6–12	Impaired [75]		Normal [75]
		>12	Normal [76, 77]/Impaired [75]	Normal [75]/impaired [76, 77]	Normal [4, 6]
		<6	Normal [78]	Impaired [78]	Impaired [78]
PDAPP	APP (V717F)	6–12
		>12	Impaired [78]	Normal [78]	Impaired [78]
		<6	Normal [79]	Impaired [79, 80]
APP/PS1	APPswe/PS1dE9	6–12	Impaired [79, 80]	Impaired [79, 80]	Normal [80]
		>12
		1-2	Normal [81]	Normal [81]	Normal [81]
3xTg-AD	APPSwe, PS1M146V, and tauP301L	3–6
		6–12	Impaired [81]	Impaired [81]	Normal [81]
		>12
5XFAD	APPswe/lnd/fl and a PS1 transgene carrying double FAD mutations (M146L and L286V)	<6	Normal [82]	Normal [82]	Normal [82]
		6–12	Impaired [82, 83]	Impaired [82, 83]	Normal [82]
		>12