Spines, Plasticity, and Cognition in Alzheimer's Model Mice

Table 2

Progressive cognitive impairments in APP AD transgenic mice.

Model	Age (months)	Spatial task		Working memory	Fear conditioning
		Learning	Probe test		Contextual	Cued
Tg2576	<6	Impaired [109]/normal [98, 100, 110]	Normal [100, 111]	Normal [110]/impaired [98]	Impaired [74, 109, 112–118]	Normal [119]
	6–12	Normal [101]/impaired [110, 120]	Normal [120]/impaired [111]	Normal [98, 101]/impaired [110]	Impaired [115, 121]/normal [122]	Normal [122]
	>12	Impaired [101, 110]	Impaired [111]	Impaired [76, 98, 101, 110]	Impaired [112, 115, 117]	Normal [112, 119]/impaired [119]
APP/PS1	<6	Normal [123–128]	Normal [126, 127]/impaired [128]	Normal [124, 127, 129, 130]/impaired [80]	Normal [131–133]/impaired [79, 117]/enhanced [127]
	6–12	Impaired [79, 80, 105, 126–128, 134]	Normal [105, 127, 134]/impaired [79, 80, 126, 128]	Impaired [80, 127, 129, 130]	Impaired [79]/normal [127]
	>12	Impaired [105, 106, 124, 128, 135]	Impaired [105, 106]	Impaired [124, 129]		Impaired [15]
3xTg-AD	1-2	Normal [107]	Normal [107]	Normal [107, 136]
	3– 6	Impaired [137–139]	Impaired [107, 137, 138]	Normal [136]
	6–12	Impaired [107, 140]	Impaired [107, 139, 140]	Impaired [136, 139, 141]	Impaired [139]
	>12		Impaired [142]	Impaired [141, 143]
5XFAD	<6		Impaired [108, 144]	Normal [102, 108]	Normal [82, 145]	Normal [144]
	6–12	Impaired [144]		Impaired [102, 103]	Impaired [82, 144, 145]
	>12			Impaired [102, 103, 146]