SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
Figure 3
Comparison of the field excitatory postsynaptic potential (fEPSP) slope changes between wild-type (WT) and Scrapper-knockout (SCR-KO) mice at different stimulation frequencies. (a) Means of 10 consecutive sweeps before and after (45–55 min) stimulation. Mean (± SEM) effect of the stimulus of the conditioning stimulation delivered at various frequencies on the response measured 50 min after conditioning (□, WT; ■, SCR-KO) (t-test). (b) Schematic model of the long-term potentiation/depression (LTP/LTD) threshold changes in SCR-KO hippocampus and the dependence on stimulus frequency.
