Mouse Brain PSA-NCAM Levels Are Altered by Graded-Controlled Cortical Impact Injury
Figure 1
Graded injury severity. Whole brain and coronal sections displaying injury severity at 24 hours in sham (a), (b), moderate (c), (d), and severe (e), (f) injury groups. Coronal H&E sections revealed no apparent hemorrhage in the underlying hippocampus in the moderate injury animals 24 hours following injury (g). Severe injury revealed extensive hippocampal and thalamic injury at the 24 hour collection point (h). Lesions on the cerebral surface were evident three weeks following severe injury (i). Moderate injury whole brain samples displayed no apparent surface defect three weeks following injury (j). Coronal sections from brain samples obtained 3 weeks after severe CCI revealed graded substantial cortical and hippocampal damage (k) while moderate CCI resulted in loss of cortical tissue and deformity and expansion of hippocampal neuropil (l). Arrows denote region of interest. Coronal sections approximate bregma −1.70. Scale bar equals 1 mm.
