Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome
Figure 1
Body weights of Ts65Dn mice and wild-type littermate controls treated with vehicle or fluoxetine (2N, vehicle: mice; 2N, fluoxetine: mice; Ts65Dn, vehicle: mice; Ts65Dn, fluoxetine: mice). Two-way ANOVA with genotype and treatment as between-subjects factors showed significant main effects of genotype (ANOVA genotype , ) and treatment (ANOVA treatment , ). Posthoc analyses showed significantly lower body weights in fluoxetine-treated Ts65Dn mice compared to vehicle-treated Ts65Dn mice (Fisher’s PLSD, ). Body weights in fluoxetine-treated 2N controls were not significantly different from 2N vehicle controls (Fisher’s PLSD, ). Graph shows mean ± SEM. *denotes comparisons where . n.s. denotes comparisons where .
