Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome
Figure 2
The figure shows the total ambulatory distance in the open field of Ts65Dn mice and wild-type controls treated with either fluoxetine or vehicle (2N, vehicle: mice; 2N, fluoxetine: mice; Ts65Dn, vehicle: mice; Ts65Dn, fluoxetine: mice). Two-way ANOVA with genotype and treatment as between-subjects factors revealed a significant effect of drug treatment on ambulatory distance (, ) and suggested a possible genotype × treatment interaction (, ). Posthoc comparison showed significantly reduced ambulatory distance in fluoxetine-treated Ts65Dn mice relative to vehicle-treated Ts65Dn animals (Fisher’s PLSD, ). In contrast, fluoxetine had no significant effect on ambulatory distance in 2N controls (Fisher’s PLSD 2N/fluoxetine versus 2N/vehicle, ). The graph shows means ± SEM. *denotes comparisons where . n.s. denotes comparisons where .
