Widespread Structural and Functional Connectivity Changes in Amyotrophic Lateral Sclerosis: Insights from Advanced Neuroimaging Research
Figure 2
Regional FA reductions in ALS patients compared with healthy controls in frontal (associative) tracts (TBSS DTI analysis performed by Cirillo et al. [24]). In (a), blue shows the superior longitudinal and the uncinate fasciculi (derived from the Johns Hopkins University White-Matter Tractography atlas [106, 107]), whilst red shows significant FA decrease in ALS patients (, corrected). (b) illustrates 3D renderings of the FA skeleton (green), where white shows regional FA reductions in patients. Remarkably, these diffusivity changes resemble those which have been described in patients with the behavioral variant of frontotemporal dementia.
