Review Article
Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities
Table 1
Behavioural and cognitive alterations in DS and in the different DS mouse models.
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Trisomy | Hsa21 | Segment of Mmu16 | Segment of Mmu17 | Segment of Mmu10 | Segment of Mmu16, Mmu17, and Mmu10 | Hsa21 | | DS | Dp(16)1Yey/+ | Ts65Dn | Ts2Cje | Ts1Cje | Ms1Ts65 | Ts1Rhr | Dep(17)1Yey/+ | Ts1Yah | Dp(10)1Yey/+ | Dp(10)1Yey/+; Dp(16)1Yey/+; Dep(17)1Yey/+ Yu et al., 2010 | Tc1 |
| | Motor skills | Delayed acquisition | | Delayed acquisition | | | | | | | | | |
| | Motor coordination | Impaired | | Impaired | | | | | | | | | Impaired |
| | Activity and attention | Reduced attention | | Hyperactivity and reduced attention | | Normal activity | Normal activity | Normal activity | | | | | Increased spontaneous activity |
| | Context discrimination | | Impaired | Impaired | | | | | Unchanged | | Unchanged | Impaired | |
| | Spatial learning and memory | Impaired | Impaired | Impaired | | Impaired | Impaired | | Unchanged | Enhanced | Unchanged | Impaired | Impaired |
| | Working and reference memory | Impaired | | Impaired | | | | | | | | | Impaired |
| | Novel object recognition | | | Impaired | | | | Impaired | | Impaired | | | |
| | Operant conditioning | | | Impaired | | | | | | | | | |
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