Review Article
Animal Models of Psychiatric Disorders That Reflect Human Copy Number Variation
Table 1
Behavioral phenotypes of mouse models.
| Human chromosomal region | Behavioral phenotypes | Reference |
| 7q11.23 (deletion) | Increased sociability |
[9] | Increased acoustic startle response | Cognitive deficits | Growth retarded (male) |
| 15q11-13 (duplication) | Decreased sociability | [10, 11] | Behavioral inflexibility | abnormal ultrasonic vocalizations | decreased spontaneous activity | Increased anxiety |
| 16p11.2 (deletion) | Hyperactive |
[12] | difficulty adapting to change | sleeping abnormalities | repetitive or restricted behaviors |
| 16p11.2 (duplication) | Hypoactive | [12] |
| 17p11.2 (deletion) | cranio facial abnormalities |
[13] | Seizures | Obesity |
| 22q11.21 (deletion)ć | Deficits in sensorimotor gating | [14, 15] | Working memory deficit | Deficit in both cued and contextual fear memory |
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