Synaptic Structure and Function in the Mouse Somatosensory Cortex
during Chronic Pain: In Vivo Two-Photon Imaging
Figure 1
Rapid and phase-specific structural plasticity of dendritic spines in the S1 following peripheral nerve injury. (a) Left panels: schematic diagram of the PSL injury model and associated investigations in the S1. Bottom graph outlines the development and maintenance phases of mechanical allodynia following PSL injury with the upper panels showing the concurrent phase-dependent increases in somatosensory-evoked potentials in the S1. Scale bars, 50 ms (horizontal) and 50 μV (vertical). (b) In vivo two-photon time-lapse images of the same S1 dendritic segment following PSL injury. Arrowheads indicate the spines that generated (red) and eliminated (blue) when compared with the previous imaging session. Scale bar, 5 μm. (c) Schematic representation of the time course of changes in spine gain/loss rates (left) and overall spine density (right) during neuropathic pain. (a–c) Reproduced and adapted, with permission, from [12].
