Synaptic Structure and Function in the Mouse Somatosensory Cortex
during Chronic Pain: In Vivo Two-Photon Imaging
Figure 2
Neuropathic pain injury increases the formation of new persistent spines and increases elimination of previously persistent spines. (a) Simplified model for spine formation (red open circles) and elimination (blue, dashed open circles) under basal conditions and during neuropathic pain. PP: previously persistent spines (black filled circles). NP: new persistent spines (red filled circles). Note the increase in NP spines (b) and decrease in PP spines (c) following PSL injury. (b and c) Reproduced and adapted, with permission, from [12].
