Figure 1: Representative low-power photomicrographs of frontal brain sections stained for PGC-1 showing the subthalamic nucleus (STN) of a control and a transgenic HD rat. Note the increased number of PGC-1-containing cells STN of the tgHD rat upon close inspection in comparison with the control subject. Scale bar is approximately 250 m. The anatomical level is approximately anteroposterior −4.16 mm from bregma according to the rat brain atlas of Paxinos and Watson of 1998. Adopted from Vlamings et al. .