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Neural Plasticity
Volume 2012 (2012), Article ID 718604, 10 pages
http://dx.doi.org/10.1155/2012/718604
Research Article

Left-Deviating Prism Adaptation in Left Neglect Patient: Reflexions on a Negative Result

1Pole de rééducation et réadaptation, Plateforme mouvement et handicap, Hôpital Henry Gabrielle, Hospices Civils de Lyon, 69000 Lyon, France
2ImpAct, INSERM (U1028), CNRS (UMR5292), Lyon Neuroscience Research Center, 69000 Lyon, France
3Université de Lyon, Université Lyon 1, F-69100, Villeurbanne, France
4Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK

Received 2 April 2012; Accepted 8 August 2012

Academic Editor: Hubert Dinse

Copyright © 2012 Jacques Luauté et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adaptation to right-deviating prisms is a promising intervention for the rehabilitation of patients with left spatial neglect. In order to test the lateral specificity of prism adaptation on left neglect, the present study evaluated the effect of left-deviating prism on straight-ahead pointing movements and on several classical neuropsychological tests in a group of five right brain-damaged patients with left spatial neglect. A group of healthy subjects was also included for comparison purposes. After a single session of exposing simple manual pointing to left-deviating prisms, contrary to healthy controls, none of the patients showed a reliable change of the straight-ahead pointing movement in the dark. No significant modification of attentional paper-and-pencil tasks was either observed immediately or 2 hours after prism adaptation. These results suggest that the therapeutic effect of prism adaptation on left spatial neglect relies on a specific lateralized mechanism. Evidence for a directional effect for prism adaptation both in terms of the side of the visuomanual adaptation and therefore possibly in terms of the side of brain affected by the stimulation is discussed.