Review Article
Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
Table 1
Critical selection of most relevant papers published in the last 13 years.
| Author | Year | Finding | Reason for selection |
| Bayer et al. [1] | 1999 | Genetic or environmental first hit affects brain development, a second hit later in life initiated the outbreak of schizophrenia | Comprehensive hypothesis concerning schizophrenia etiology |
|
Arnold and Watt [21] | 2001 | Number of immature cells is increased in the olfactory epithelium of schizophrenics | First report on altered cell density in schizophrenics |
| Reif et al. [22] | 2006 | Cell proliferation is diminished in the dentate gyrus of schizophrenics | First report on altered cell proliferation in the human brain |
| Kippin et al. [23] Wakade et al. [24] Wang et al. [25] | 2005 2002 2004 | Typical and atypical neuroleptics enhance neurogenesis in the subventricular zone | Effects of neuroleptics on neurogenesis in the subventricular zone |
| Kodama et al. [26] Wakade et al. [24] Halim et al. [27] | 2004 2002 2004 | Atypical but not typical neuroleptics interfere with hippocampal neurogenesis | Effects of neuroleptics on neurogenesis in the hippocampus |
| Piontkewitz et al. [28] | 2012 | Risperidone partially restored impaired neurogenesis in poly I:C offspring | Effect of an atypical neuroleptic on neurogenesis in an model of maternal infection |
| Keilhoff et al. [29] | 2010 | Subchronic treatment with haloperidol ameliorated decreased neurogenesis and normalised behaviour in vitamin D-deficient rats | Effect of neuroleptics on neurogenesis in the vitamin D model |
| Keilhoff et al. [30] | 2010 | Risperidone and haloperidol promoted survival in stem cells in the hippocampus of rats subchronically treated with ketamine | Effects of typical and atypical neuroleptics on neurogenesis in the ketamine model |
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