|
| Species | Stress paradigm | Experimental approach | Effects on neurogenesis | Effects on behavior | References |
|
| Physical stress |
|
| Sprague-Dawley rat | Acute restraint stress:
either 2 or 6hours.
Chronic restraint stress:
6 hours daily for 21 days.
Repeated restraint stress:
6 hours daily for 42 days. | Proliferation: BrdU (1 × 200 mg/kg, ip) at 2 hours pulsing chase
Survival: BrdU (100 mg/kg, ip) daily for 4 days and analysis on 12 days to 3 weeks periods after BrdU injection.
| Acute stress: no effect on cell proliferation.
Chronic stress: Decreased cell proliferation, slightly decreased survival rate with no statistical significance.
Repeated stress: decreased survival rate. | Not studied (NS) | [11] |
|
| Sprague-Dawley rat | 60 inescapable foot shocks | Proliferation: BrdU (1 × 100 mg/kg, ip) at 2 hours pulsing chase.
Survival: BrdU (100 mg/kg, ip) on day 9 and analysis 28 days later. | Decreased cell proliferation.
No change on survival rate and differentiation. | NS | [12] |
|
| ICR mouse | Chronic restraint stress: 6 hours per day for four weeks. | Proliferation: Ki67 immunostaining.
Survival: BrdU (3 × 75 mg/kg, ip) at 6-hour intervals and 24 hours before exposure to chronic restraint stress. | Decreased cell proliferation and survival rate. | Impaired context dependent memory. | [13]
|
|
| Wistar rat | Olfactory bulbectomy
(OB). | Proliferation: BrdU (1 × 40 mg/kg, ip) at 2 hours pulsing chase.
Survival: BrdU (3 × 200 mg/kg, ip) at 2-hour intervals and analysis 4 weeks after last administration. | Decreased cell proliferation and neuronal differentiation. | Impaired context-dependent memory. | [14] |
|
| Social stress |
|
| Sprague-Dawley rat | Psychosocial stress by introducing intruder animal. | Proliferation: IdU (4 × 57.5 mg/kg, ip) at 12-hour intervals. IdU at 3-day pulsing chase after the first administration.
Short-term survival: BrdU (6 × 50 mg/kg, ip), 12-hour intervals. BrdU at 10-day pulsing chase after first administration. | No change on cell proliferation, but decreased short-term survival rate. | NS | [15] |
|
| Prairie vole | Social isolation: single-housed for 6 weeks. | Proliferation: Ki67 immunostaining.
Survival: BrdU (100 mg/kg, ip) daily for fourteen consecutive days and then 6-week pulsing chase after last administration. | Decreased cell proliferation and neuronal maturation. | Higher levels of anxiety-like and depression-like behaviors | [16] |
|
| Wistar rat | Social defeat stress daily for 18 days | Proliferation: BrdU (200 mg/kg, ip) at 24-hour pulsing chase.
Survival: BrdU (200 mg/kg, ip) two times per day for 2 days. | Decreased cell proliferation and survival rate. | NS | [17] |
|
