Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus

Figure 2

Colocalization of dopamine receptors and glutamate receptors leads to activation of intracellular transduction mechanisms, induction of regulatory transcription factors, and ultimately long-term changes in cellular plasticity in the hippocampus. AC: adenylyl cyclase, AMPA: α-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid receptor, CREB: cAMP-response element binding protein, DA:dopamine, DARPP-32: Dopamine, cAMP-regulated phosphoprotein of 32,000 kDa, ERK: extracellular signal-regulated kinase, GLU: glutamate, GluR5:Metabolic glutamate receptor type 5, MAPK: mitogen-activated protein kinase, NMDA: N-methyl d-aspartate receptor, PKA: protein kinase A, VGCC: voltage-gated calcium channel. (Adopted and modified from [13]).