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Figure 5: Endocannabinoids negatively regulate ghrelin-induced enhancement of synaptic receptor functions by inhibiting the phosphorylation of NR1. CB1R (type 1 cannabinoid receptor), GHSR1a (type 1a ghrelin receptor, aka growth hormone secretagogue receptor), PKA (protein kinase A), RYR (ryanodine receptor), ER (endoplasmic reticulum), L-VGCC (L-type voltage-gated calcium channel), 2-AG (2-arachidonoyl glycerol).