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Neural Plasticity
Volume 2013 (2013), Article ID 258582, 9 pages
http://dx.doi.org/10.1155/2013/258582
Review Article

Influence of Inflammation on Poststroke Plasticity

1Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, Polish Academy of Science, 3 Pasteur Street, 02-093 Warsaw, Poland
2Warsaw School of Social Science and Humanities, 19 Chodakowska Street, 03-815 Warsaw, Poland

Received 27 November 2012; Accepted 11 January 2013

Academic Editor: Michael Stewart

Copyright © 2013 Monika Liguz-Lecznar and Malgorzata Kossut. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Age-related brain injuries including stroke are a leading cause of morbidity and mental disability worldwide. Most patients who survive stroke experience some degree of recovery. The restoration of lost functions can be explained by neuronal plasticity, understood as brain ability to reorganize and remodel itself in response to changed environmental requirements. However, stroke triggers a cascade of events which may prevent the normal development of the plastic changes. One of them may be inflammatory response initiated immediately after stroke, which has been found to contribute to neuronal injury. Some recent evidence though has suggested that inflammatory reaction can be also neuroprotective. This paper attempts to discuss the influence of poststroke inflammatory response on brain plasticity and stroke outcome. We also describe the recent anti-inflammatory strategies that have been effective for recovery in experimental stroke.