Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model

Figure 3

The rotation rate of the subgroup PD rats (arrow indicates the operation, intraSTN injection of rAAV2-hGAD65, rAAV2 vector, or PBS and/or intrastriatal injection of fibroblasts (TH), fibroblast). The cycles of the rats of combination group were a little lower than that of rAAV2-hGAD65, or fibroblasts (TH) groups, but there were no statistical differences between them (𝑃>0.05, 𝑛=10). The cycles of the rats of combination, rAAV2-hGAD65, or fibroblasts (TH) groups were all significantly lower than that the control groups (fibroblasts, rAAV2 vector or PBS groups) from 4 to 16 weeks after treatment, respectively (𝑃<0.01, 𝑛=10).