Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model
Figure 6
GABA and glutamic acid concentrations in the GPi and SNr tissues. (a and b) The concentrations of GABA in the GPi and SNr tissues of combination group were a little lower than that of rAAV2-hGAD65 and fibroblasts (TH) groups (, ). But the GABA concentrations in these three groups were all obviously lower than that of the three control groups (fibroblasts, rAAV2 vector, and PBS) at 4, 8, and 16 weeks after treatment (, ). (c and d) The changing tendency of the concentration of the glutamic acid was similar to the change of the GABA in GPi and SNr at the 4, 8, and 16 weeks after treatment (, ). Fibroblasts (TH), fibroblasts transferred by rAd-TH; fibroblasts, the primary cultured fibroblasts; rAAV2-hGAD65, recombinant adeno-associated virus particles containing human glutamic acid decarboxylase 65; rAAV2 vector, control adeno-associated virus pedicles; combination, rAAV2-hGAD65 + fibroblasts (TH); PBS, inject the PBS into the STN.
