Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model
Figure 8
Immunohistochemistry of fibroblasts expressing TH in the striatum (DAB, bar = 100 μm). A large number of TH-positive cells are observed in the left striatum around the pin track in fibroblasts (TH) group, but there are no positive cells in either hemispheres of the rAAV2-hGAD65 group. The number of TH-positive cells decreased according to posttreatment time: 4 weeks (a), 8 weeks (b), and 16 weeks (c). There was no TH-positive cell around the pin track in the left striatum of fibroblast at 4 weeks after treatment (d).
