The Plasma Membrane Ca2+-ATPase2 (PMCA2) Is Involved in the Regulation of Purkinje Cell Dendritic Growth in Cerebellar Organotypic Slice Cultures
Figure 4
(a) Size of Purkinje cell dendritic arbors with different pharmacological treatments: The mean size of control Purkinje cells was considered as 100%. Dendritic tree size was reduced to 48% of control with DHPG treatment. Cotreatment with carboxyeosin resulted in a rescue of the dendritic area to 70% of the control value, similar to the size after treatment with carboxyeosin alone. These differences were significant with (***). Error bars represent the SEM. (b) Number of branch points with the pharmacological treatments: The mean number of branch points of control Purkinje cells was considered as 100%. The branchpoint number is reduced to 37% in DHPG treated cultures compared to control. Cotreatment with carboxyeosin showed a rescue of the branch points to 70% of the control value. These differences were significant with (***). Error bars represent the SEM.
