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Neural Plasticity
Volume 2013 (2013), Article ID 359532, 7 pages
http://dx.doi.org/10.1155/2013/359532
Research Article

Maturation of Corpus Callosum Anterior Midbody Is Associated with Neonatal Motor Function in Eight Preterm-Born Infants

1Perinatal Research Centre and UQ Centre for Clinical Research, The University of Queensland and Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029, Australia
2School of Psychology and Psychiatry, Monash University, Melbourne, VIC 3806, Australia
3Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD 4027, Australia
4Infant Neurology Section, Stella Maris Scientific Institute, 56018 Pisa, Italy
5Grantley Stable Neonatal Unit, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029, Australia

Received 7 October 2012; Accepted 26 December 2012

Academic Editor: Giorgio M. Innocenti

Copyright © 2013 Preethi Mathew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The etiology of motor impairments in preterm infants is multifactorial and incompletely understood. Whether corpus callosum development is related to impaired motor function is unclear. Potential associations between motor-related measures and diffusion tensor imaging (DTI) of the corpus callosum in preterm infants were explored. Methods. Eight very preterm infants (gestational age of 28–32 weeks) underwent the Hammersmith neonatal neurological examination and DTI assessments at gestational age of 42 weeks. The total Hammersmith score and a motor-specific score (sum of Hammersmith motor subcategories) were calculated. Six corpus callosum regions of interest were defined on the mid-sagittal DTI slice—genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium. The fractional anisotropy (FA) and mean diffusivity (MD) of these regions were computed, and correlations between these and Hammersmith measures were sought. Results. Anterior midbody FA measures correlated positively with total Hammersmith (rho , ) and motor-specific scores (rho , ). Total Hammersmith scores also negatively correlated with anterior midbody MD measures (rho , ). Discussion. These results suggest the integrity of corpus callosum axons, particularly anterior midbody axons, is important in mediating neurological functions. Greater callosal maturation was associated with greater motor function. Corpus callosum DTI may prove to be a valuable screening or prognostic marker.