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Neural Plasticity
Volume 2013 (2013), Article ID 424651, 6 pages
Review Article

Methylcobalamin: A Potential Vitamin of Pain Killer

Institute of Neurosciences, The Fourth Military Medical University, Xi’an 710032, China

Received 19 September 2013; Revised 6 November 2013; Accepted 12 November 2013

Academic Editor: Sheng Tian Li

Copyright © 2013 Ming Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. R. McDowell, Vitamins in Animal and Human Nutrition, John Wiley & Sons, 2008.
  2. R. Banerjee and S. W. Ragsdale, “The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes,” Annual Review of Biochemistry, vol. 72, pp. 209–247, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. S. K. Ghosh, N. Rawal, S. K. Syed, W. K. Paik, and S. D. Kim, “Enzymic methylation of myelin basic protein in myelin,” Biochemical Journal, vol. 275, part 2, pp. 381–387, 1991. View at Scopus
  4. A. Pfohl-Leszkowicz, G. Keith, and G. Dirheimer, “Effect of cobalamin derivatives on in vitro enzymatic DNA methylation: methylcobalamin can act as a methyl donor,” Biochemistry, vol. 30, no. 32, pp. 8045–8051, 1991. View at Scopus
  5. J. I. Toohey, “Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?” BioFactors, vol. 26, no. 1, pp. 45–57, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Takahashi, S. Usui, and Y. Honda, “Effect of vitamin B12 (mecobalamin) on the circadian rhythm of rat behavior,” Clinical Neuropharmacology, vol. 15, supplement 1, part A, pp. 46A–47A, 1992. View at Scopus
  7. A. McCaddon and P. R. Hudson, “L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline,” CNS Spectrums, vol. 15, supplement 1, no. 1, pp. 2–6, 2010. View at Scopus
  8. T. Ikeda, K. Yamamoto, K. Takahashi et al., “Treatment of Alzheimer-type dementia with intravenous mecobalamin,” Clinical Therapeutics, vol. 14, no. 3, pp. 426–437, 1992. View at Scopus
  9. M. Kikuchi, S. Kashii, Y. Honda, Y. Tamura, K. Kaneda, and A. Akaike, “Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture,” Investigative Ophthalmology and Visual Science, vol. 38, no. 5, pp. 848–854, 1997. View at Scopus
  10. X. Kong, X. Sun, and J. Zhang, “The protective role of Mecobalamin following optic nerve crush in adult rats,” Yan Ke Xue Bao, vol. 20, no. 3, pp. 171–177, 2004. View at Scopus
  11. A. Akaike, Y. Tamura, Y. Sato, and T. Yokota, “Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons,” European Journal of Pharmacology, vol. 241, no. 1, pp. 1–6, 1993. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Devathasan, W. L. Teo, and A. Mylvaganam, “Methylcobalamin in chronic diabetic neuropathy. A double-blind clinical and electrophysiological study,” Clinical Trials Journal, vol. 23, no. 2, pp. 130–140, 1986. View at Scopus
  13. S. Kuwabara, R. Nakazawa, N. Azuma et al., “Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients,” Internal Medicine, vol. 38, no. 6, pp. 472–475, 1999. View at Scopus
  14. H. Ishihara, M. Yoneda, W. Yamamoto, et al., “Efficacy of intravenous administration of methycobalamin for diabetic peripheral neuropathy,” Med Consult N Remedies, vol. 29, no. 1, pp. 1720–1725, 1992.
  15. M. Sonobe, H. Yasuda, I. Hatanaka et al., “Methylcobalamin improves nerve conduction in streptozotocin-diabetic rats without affecting sorbitol and myo-inositol contents of sciatic nerve,” Hormone and Metabolic Research, vol. 20, no. 11, pp. 717–718, 1988. View at Scopus
  16. T. Watanabe, R. Kaji, N. Oka, W. Bara, and J. Kimura, “Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy,” Journal of the Neurological Sciences, vol. 122, no. 2, pp. 140–143, 1994. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Iwasaki and S. Kurimoto, “Effect of methylcobalamin in accommodative dysfunction of eye by visual load,” Journal of UOEH, vol. 9, no. 2, pp. 127–132, 1987. View at Scopus
  18. M. Yamashiki, A. Nishimura, and Y. Kosaka, “Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells,” Journal of Clinical and Laboratory Immunology, vol. 37, no. 4, pp. 173–182, 1992. View at Scopus
  19. M. Ikeda, M. Asai, T. Moriya, M. Sagara, S. Inoué, and S. Shibata, “Methylcobalamin amplifies melatonin-induced circadian phase shifts by facilitation of melatonin synthesis in the rat pineal gland,” Brain Research, vol. 795, no. 1-2, pp. 98–104, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Takahashi, M. Okawa, M. Matsumoto et al., “Double-blind test on the efficacy of methylcobalamin on sleep-wake rhythm disorders,” Psychiatry and Clinical Neurosciences, vol. 53, no. 2, pp. 211–213, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Ide, S. Fujiya, Y. Asanuma, M. Tsuji, H. Sakai, and Y. Agishi, “Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy,” Clinical Therapeutics, vol. 9, no. 2, pp. 183–192, 1987. View at Scopus
  22. G. Li, “Effect of mecobalamin on diabetic neuropathies. Beijing Methycobal Clinical Trial Collaborative Group,” Zhonghua Nei Ke Za Zhi, vol. 38, no. 1, pp. 14–17, 1999. View at Scopus
  23. Y. U. Dongre and O. C. Swami, “Sustained-release pregabalin with methylcobalamin in neuropathic pain: an Indian real-life experience,” International Journal of General Medicine, vol. 6, pp. 413–417, 2013.
  24. J. W. Frymoyer, “Back pain and sciatica,” The New England Journal of Medicine, vol. 318, no. 5, pp. 291–300, 1988. View at Scopus
  25. W. Waikakul and S. Waikakul, “Methylcobalamin as an adjuvant medication in conservative treatment of lumbar spinal stenosis,” Journal of the Medical Association of Thailand, vol. 83, no. 8, pp. 825–831, 2000. View at Scopus
  26. C. K. Chiu, T. H. Low, Y. S. Tey, V. A. Singh, and H. K. Shong, “The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial,” Singapore Medical Journal, vol. 52, no. 12, pp. 868–873, 2011. View at Scopus
  27. L. Manchikanti, E. E. Dunbar, B. W. Wargo, R. V. Shah, R. Derby, and S. P. Cohen, “Systematic review of cervical discography as a diagnostic test for chronic spinal pain,” Pain Physician, vol. 12, no. 2, pp. 305–321, 2009. View at Scopus
  28. L. Manchikanti, S. Abdi, S. Atluri, et al., “American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: part I—evidence assessment,” Pain Physician, vol. 15, no. 3, pp. S1–S65, 2012.
  29. I. Y. Hanai, M. K'Yatsume, et al., “Clinical study of methylcobalamin on cervicales,” Drug Therapy, vol. 13, no. 4, p. 29, 1980.
  30. G. Xu, Z. W. Lv, Y. Feng, W. Z. Tang, and G. X. Xu, “A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia,” Pain Medicine, vol. 14, no. 6, pp. 884–894, 2013.
  31. P. M. Singh, M. Dehran, V. K. Mohan, A. Trikha, and M. Kaur, “Analgesic efficacy and safety of medical therapy alone vs combined medical therapy and extraoral glossopharyngeal nerve block in glossopharyngeal neuralgia,” Pain Medicine, vol. 14, pp. 93–102, 2013.
  32. J. Teramoto, “Effects of Methylcobalamin on neuralgia,” Neurological Therapeutics, vol. 1, no. 2, p. 315, 1984.
  33. A. S. Morani and S. L. Bodhankar, “Neuroprotecive effect of early treatment with pioglitasone and methylcobalamin in alloxan induced diabetes in rats,” Pharmacologyonline, vol. 3, pp. 282–293, 2007. View at Scopus
  34. A. S. Morani and S. L. Bodhankar, “Early co-administration of vitamin E acetate and methylcobalamin improves thermal hyperalgesia and motor nerve conduction velocity following sciatic nerve crush injury in rats,” Pharmacological Reports, vol. 62, no. 2, pp. 405–409, 2010. View at Scopus
  35. I. Jurna, “Analgesic and analgesia-potentiating action of B vitamins,” Schmerz, vol. 12, no. 2, pp. 136–141, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. Y. Sun, M. S. Lai, and C. J. Lu, “Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials,” Acta Neurologica Taiwanica, vol. 14, no. 2, pp. 48–54, 2005. View at Scopus
  37. K. Okada, H. Tanaka, K. Temporin et al., “Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model,” Experimental Neurology, vol. 222, no. 2, pp. 191–203, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Yamatsu, Y. Yamanishi, T. Kaneko, and I. Ohkawa, “Pharmacological studies on degeneration and regeneration of peripheral nerves. (II). Effects of methylcobalamin on mitosis of Schwann cells and incorporation of radio active leucine into protein fraction of crushed sciatic nerve in rats,” Folia Pharmacologica Japonica, vol. 72, no. 2, pp. 269–278, 1976 (Japanese). View at Scopus
  39. K. Yamazaki, K. Oda, C. Endo, T. Kikuchi, and T. Wakabayashi, “Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse,” Neuroscience Letters, vol. 170, no. 1, pp. 195–197, 1994. View at Publisher · View at Google Scholar · View at Scopus
  40. A. M. Jacobs and D. Cheng, “Management of diabetic small-fiber neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5′-phosphate,” Reviews in Neurological Diseases, vol. 8, no. 1-2, pp. 39–47, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. W.-H. Xiao and G. J. Bennett, “Synthetic ω-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats,” Journal of Pharmacology and Experimental Therapeutics, vol. 274, no. 2, pp. 666–672, 1995. View at Scopus
  42. Y. W. Yoon, H. S. Na, and J. M. Chung, “Contributions of injured and intact afferents to neuropathic pain in an experimental rat model,” Pain, vol. 64, no. 1, pp. 27–36, 1996. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. S. Lyu, S. K. Park, K. Chung, and J. M. Chung, “Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model,” Brain Research, vol. 871, no. 1, pp. 98–103, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Lai, M. S. Gold, C. S. Kim et al., “Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8,” Pain, vol. 95, no. 1-2, pp. 143–152, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. S. R. Chaplan, H.-Q. Guo, D. H. Lee et al., “Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain,” The Journal of Neuroscience, vol. 23, no. 4, pp. 1169–1178, 2003. View at Scopus
  46. I. T. Atsuta Y, O. Sugawara, T. Muramoto, T. Watakabe, and Y. Takemitsu, “The study of generating and suppressive factors of ectopic firing in the lumbar dorsal root using an in vitro model,” Rinsho Seikei Geka, vol. 29, pp. 441–446, 1994.