Table 2: The analgesic effects of MeCbl on low back pain and neck pain in clinical trials.

Effects of MeCbl Indices Measures of intervention Reference

Relieved spontaneous pain, allodynia, and paresthesia.Pain symptoms of patients with neck painOral administration of MeCbl for 4 weeksHanai et al. [29]

Amelioration of neurogenic claudication distance; no effect on pain improvement and neurological signsPain symptoms; measure the neurogenic claudication distance of patients with degenerative lumbar spinal stenosisOral administration of MeCbl as an adjuvant medication for 6 monthsW. Waikakul and S. Waikakul [25]

Reduced pain Oswestry disability index questionnaire (ODI) and visual analogue scale (VAS) pain score of patients with nonspecific low back painIntramuscular injection of MeCbl for 2 weeksChiu et al. [26]