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Volume 2013 (2013), Article ID 438072, 8 pages
Environment, Leptin Sensitivity, and Hypothalamic Plasticity
1CNR Neuroscience Institute, Via Moruzzi 1, 56124 Pisa, Italy
2Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Via San Salvi 12, 50135 Florence, Italy
3Dulbecco Telethon Institute at Endocrinology Unit, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy
4CNR Institute of Food Sciences, Via Roma 64, 83100 Avellino, Italy
Received 5 April 2013; Accepted 25 June 2013
Academic Editor: Alessandro Sale
Copyright © 2013 Marco Mainardi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. W. Schwartz, S. C. Woods, D. Porte Jr., R. J. Seeley, and D. G. Baskin, “Central nervous system control of food intake,” Nature, vol. 404, no. 6778, pp. 661–671, 2000.
- E. E. Jobst, P. J. Enriori, and M. A. Cowley, “The electrophysiology of feeding circuits,” Trends in Endocrinology and Metabolism, vol. 15, no. 10, pp. 488–499, 2004.
- M. S. Dicken, R. E. Tooker, and S. T. Hentges, “Regulation of gaba and glutamate release from proopiomelanocortin neuron terminals in intact hypothalamic networks,” The Journal of Neuroscience, vol. 32, no. 12, pp. 4042–4048, 2012.
- M. G. Myers Jr., H. Münzberg, G. M. Leinninger, and R. L. Leshan, “The geometry of leptin action in the brain: more complicated than a simple ARC,” Cell Metabolism, vol. 9, no. 2, pp. 117–123, 2009.
- L. Plum, B. F. Belgardt, and J. C. Brüning, “Central insulin action in energy and glucose homeostasis,” The Journal of Clinical Investigation, vol. 116, no. 7, pp. 1761–1766, 2006.
- J.-H. Wang, F. Wang, M.-J. Yang et al., “Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways,” Neuroscience, vol. 156, no. 1, pp. 89–98, 2008.
- J. Qiu, Y. Fang, O. K. Rønnekleiv, and M. J. Kelly, “Leptin excites proopiomelanocortin neurons via activation of TRPC channels,” The Journal of Neuroscience, vol. 30, no. 4, pp. 1560–1565, 2010.
- H. T. Bergen, T. M. Mizuno, J. Taylor, and C. V. Mobbs, “Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin,” Endocrinology, vol. 139, no. 11, pp. 4483–4488, 1998.
- L. Yaswen, N. Diehl, M. B. Brennan, and U. Hochgeschwender, “Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin,” Nature Medicine, vol. 5, no. 9, pp. 1066–1070, 1999.
- E. Gropp, M. Shanabrough, E. Borok et al., “Agouti-related peptide-expressing neurons are mandatory for feeding,” Nature Neuroscience, vol. 8, no. 10, pp. 1289–1291, 2005.
- A. Mesaros, S. B. Koralov, E. Rother et al., “Activation of Stat3 signaling in AgRP neurons promotes locomotor activity,” Cell Metabolism, vol. 7, no. 3, pp. 236–248, 2008.
- Y. Aponte, D. Atasoy, and S. M. Sternson, “AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training,” Nature Neuroscience, vol. 14, no. 3, pp. 351–355, 2011.
- C. Zhan, J. Zhou, Q. Feng, et al., “Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively,” The Journal of Neuroscience, vol. 33, no. 8, pp. 3624–3632, 2013.
- F. Zhang, V. Gradinaru, A. R. Adamantidis et al., “Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures,” Nature Protocols, vol. 5, no. 3, pp. 439–456, 2010.
- V. K. Yadav, F. Oury, N. Suda et al., “A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure,” Cell, vol. 138, no. 5, pp. 976–989, 2009.
- J. M. Friedman and J. L. Halaas, “Leptin and the regulation of body weight in mammals,” Nature, vol. 395, no. 6704, pp. 763–770, 1998.
- P. Lindström, “The physiology of obese-hyperglycemic mice [ob/ob mice],” The Scientific World Journal, vol. 7, pp. 666–685, 2007.
- F. F. Chehab, “A broader role for leptin,” Nature Medicine, vol. 2, no. 7, pp. 723–724, 1996.
- J. L. Halaas, K. S. Gajiwala, M. Maffei et al., “Weight-reducing effects of the plasma protein encoded by the obese gene,” Science, vol. 269, no. 5223, pp. 543–546, 1995.
- M. A. Pelleymounter, M. J. Cullen, M. B. Baker et al., “Effects of the obese gene product on body weight regulation in ob/ob mice,” Science, vol. 269, no. 5223, pp. 540–543, 1995.
- J. Salvador, J. Gomez-Ambrosi, and G. Fühbeck, “Perspectives in the therapeutic use of leptin,” Expert Opinion on Pharmacotherapy, vol. 2, no. 10, pp. 1615–1622, 2001.
- I. Sadaf Farooqi and S. O'Rahilly, “Leptin: a pivotal regulator of human energy homeostasis,” American Journal of Clinical Nutrition, vol. 89, no. 3, pp. 980S–984S, 2009.
- Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman, “Positional cloning of the mouse obese gene and its human homologue,” Nature, vol. 372, no. 6505, pp. 425–432, 1994.
- D. L. Coleman, “A historical perspective on leptin,” Nature Medicine, vol. 16, no. 10, pp. 1097–1099, 2010.
- M.-D. Li, “Leptin and beyond: an odyssey to the central control of body weight,” Yale Journal of Biology and Medicine, vol. 84, no. 1, pp. 1–7, 2011.
- G.-H. Lee, R. Proenca, J. M. Montez et al., “Abnormal splicing of the leptin receptor in diabetic mice,” Nature, vol. 379, no. 6566, pp. 632–635, 1996.
- E. Ravussin, R. E. Pratley, M. Maffei et al., “Relatively low plasma leptin concentrations precede weight gain in Pima Indians,” Nature Medicine, vol. 3, no. 2, pp. 238–240, 1997.
- M. Maffei, H. Fei, G.-H. Lee et al., “Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 15, pp. 6957–6960, 1995.
- L. A. Tartaglia, M. Dembski, X. Weng et al., “Identification and expression cloning of a leptin receptor, OB-R,” Cell, vol. 83, no. 7, pp. 1263–1271, 1995.
- M. E. Trujillo, M.-J. Lee, S. Sullivan et al., “Tumor necrosis factor α and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 4, pp. 1484–1490, 2006.
- S. K. Fried, M. R. Ricci, C. D. Russell, and B. Laferrère, “Regulation of leptin production in humans,” The Journal of Nutrition, vol. 130, no. 12, pp. 3127S–3131S, 2000.
- M. Mapfei, J. Halaas, E. Ravussin et al., “Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects,” Nature Medicine, vol. 1, no. 11, pp. 1155–1161, 1995.
- A. Parduca, J. Perez, and L. M. Garcia-Segura, “Estradiol induces plasticity of GABAergic synapses in the hypothalamus,” Neuroscience, vol. 53, no. 2, pp. 395–401, 1993.
- E. Csakvari, Z. Hoyk, A. Gyenes, D. Garcia-Ovejero, L. M. Garcia-Segura, and Á. Párducz, “Fluctuation of synapse density in the arcuate nucleus during the estrous cycle,” Neuroscience, vol. 144, no. 4, pp. 1288–1292, 2007.
- L. M. Zeltser, R. J. Seeley, and M. H. Tschop, “Synaptic plasticity in neuronal circuits regulating energy balance,” Nature Neuroscience, vol. 15, no. 10, pp. 1336–1342, 2012.
- S. G. Bouret, S. J. Draper, and R. B. Simerly, “Trophic action of leptin on hypothalamic neurons that regulate feeding,” Science, vol. 304, no. 5667, pp. 108–110, 2004.
- N. Berardi, T. Pizzorusso, and L. Maffei, “Critical periods during sensory development,” Current Opinion in Neurobiology, vol. 10, no. 1, pp. 138–145, 2000.
- S. Pinto, A. G. Roseberry, H. Liu et al., “Rapid rewiring of arcuate nucleus feeding circuits by leptin,” Science, vol. 304, no. 5667, pp. 110–115, 2004.
- C. M. Novak, P. R. Burghardt, and J. A. Levine, “The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward,” Neuroscience and Biobehavioral Reviews, vol. 36, no. 3, pp. 1001–1014, 2012.
- R. A. Hammond, “Social influence and obesity,” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 17, no. 5, pp. 467–471, 2010.
- D. E. G. McNay, N. Briançon, M. V. Kokoeva, E. Maratos-Flier, and J. S. Flier, “Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice,” The Journal of Clinical Investigation, vol. 122, no. 1, pp. 142–152, 2012.
- C. M. Patterson, S. G. Bouret, A. A. Dunn-Meynell, and B. E. Levin, “Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling,” American Journal of Physiology, vol. 296, no. 3, pp. R537–R548, 2009.
- S. K. Panchal and L. Brown, “Rodent models for metabolic syndrome research,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 351982, 14 pages, 2011.
- E. M. Mercken, B. A. Carboneau, S. M. Krzysik-Walker, and R. de Cabo, “Of mice and men: the benefits of caloric restriction, exercise, and mimetics,” Ageing Research Reviews, vol. 11, no. 3, pp. 390–398, 2012.
- B. Martin, M. P. Mattson, and S. Maudsley, “Caloric restriction and intermittent fasting: two potential diets for successful brain aging,” Ageing Research Reviews, vol. 5, no. 3, pp. 332–353, 2006.
- A. Coppola, Z.-W. Liu, Z. B. Andrews et al., “A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2,” Cell Metabolism, vol. 5, no. 1, pp. 21–33, 2007.
- M. Mainardi, G. Scabia, T. Vottari et al., “A sensitive period for environmental regulation of eating behavior and leptin sensitivity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 38, pp. 16673–16678, 2010.
- A. Sale, N. Berardi, and L. Maffei, “Enrich the environment to empower the brain,” Trends in Neurosciences, vol. 32, no. 4, pp. 233–239, 2009.
- H. van Praag, G. Kempermann, and F. H. Gage, “Neural consequences of environmental enrichment,” Nature Reviews Neuroscience, vol. 1, no. 3, pp. 191–198, 2000.
- G. Di Cristo, B. Chattopadhyaya, S. J. Kuhlman et al., “Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity,” Nature Neuroscience, vol. 10, no. 12, pp. 1569–1577, 2007.
- A. Benani, C. Hryhorczuk, A. Gouazé, et al., “Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice,” The Journal of Neuroscience, vol. 32, no. 35, pp. 11970–11979, 2012.
- G. Lluri, G. D. Langlois, P. D. Soloway, and D. M. Jaworski, “Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates myogenesis and β1 integrin expression in vitro,” Experimental Cell Research, vol. 314, no. 1, pp. 11–24, 2008.
- J. Gray, G. S. H. Yeo, J. J. Cox et al., “Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene,” Diabetes, vol. 55, no. 12, pp. 3366–3371, 2006.
- B. Xu, E. H. Goulding, K. Zang et al., “Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor,” Nature Neuroscience, vol. 6, no. 7, pp. 736–742, 2003.
- C. A. Altar and P. S. Distefano, “Neurotrophin trafficking by anterograde transport,” Trends in Neurosciences, vol. 21, no. 10, pp. 433–437, 1998.
- A. Barco, S. Patterson, J. M. Alarcon et al., “Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture,” Neuron, vol. 48, no. 1, pp. 123–137, 2005.
- J. Cordeira and M. Rios, “Weighing in the role of BDNF in the central control of eating behavior,” Molecular Neurobiology, vol. 44, no. 3, pp. 441–448, 2011.
- L. Minichiello, A. M. Calella, D. L. Medina, T. Bonhoeffer, R. Klein, and M. Korte, “Mechanism of TrkB-mediated hippocampal long-term potentiation,” Neuron, vol. 36, no. 1, pp. 121–137, 2002.
- J.-S. Mu, W.-P. Li, Z.-B. Yao, and X.-F. Zhou, “Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats,” Brain Research, vol. 835, no. 2, pp. 259–265, 1999.
- A. Bartoletti, L. Cancedda, S. W. Reid et al., “Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation,” The Journal of Neuroscience, vol. 22, no. 23, pp. 10072–10077, 2002.
- L. Cancedda, E. Putignano, A. Sale, A. Viegi, N. Berardi, and L. Maffei, “Acceleration of visual system development by environmental enrichment,” The Journal of Neuroscience, vol. 24, no. 20, pp. 4840–4848, 2004.
- A. Sale, J. F. Maya Vetencourt, P. Medini et al., “Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition,” Nature Neuroscience, vol. 10, no. 6, pp. 679–681, 2007.
- L. Cao, X. Liu, E.-J. D. Lin et al., “Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition,” Cell, vol. 142, no. 1, pp. 52–64, 2010.
- S. Stanley, S. Pinto, J. Segal et al., “Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 15, pp. 7024–7029, 2010.
- L. Cao, E. Y. Choi, X. Liu et al., “White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis,” Cell Metabolism, vol. 14, no. 3, pp. 324–338, 2011.
- M. A. Cowley, J. L. Smart, M. Rubinstein et al., “Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus,” Nature, vol. 411, no. 6836, pp. 480–484, 2001.
- M. Mainardi, S. Landi, L. Gianfranceschi et al., “Environmental enrichment potentiates thalamocortical transmission and plasticity in the adult rat visual cortex,” Journal of Neuroscience Research, vol. 88, no. 14, pp. 3048–3059, 2010.
- M. V. Kokoeva, H. Yin, and J. S. Flier, “Neurogenesis in the hypothalamus of adult mice: potential role in energy balance,” Science, vol. 310, no. 5748, pp. 679–683, 2005.
- J. Brown, C. M. Cooper-Kuhn, G. Kempermann et al., “Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis,” European Journal of Neuroscience, vol. 17, no. 10, pp. 2042–2046, 2003.
- Z. B. Yu, S. P. Han, X. G. Cao, and X. R. Guo, “Intelligence in relation to obesity: a systematic review and meta-analysis,” Obesity Reviews, vol. 11, no. 9, pp. 656–670, 2010.
- J. G. Mercer, N. Hoggard, L. M. Williams, C. B. Lawrence, L. T. Hannah, and P. Trayhurn, “Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization,” FEBS Letters, vol. 387, no. 2-3, pp. 113–116, 1996.
- C. A. Grillo, G. G. Piroli, A. N. Evans et al., “Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction,” Physiology and Behavior, vol. 104, no. 2, pp. 235–241, 2011.
- Y. Morikawa, E. Ueyama, and E. Senba, “Fasting-induced activation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus,” Journal of Neuroendocrinology, vol. 16, no. 2, pp. 105–112, 2004.
- S. Davis and S. Laroche, “Mitogen-activated protein kinase/extracellular regulated kinase signalling and memory stabilization: a review,” Genes, Brain and Behavior, vol. 5, supplement 2, pp. 61–72, 2006.
- G. Di Cristo, N. Berardi, L. Cancedda et al., “Requirement of ERK activation for visual cortical plasticity,” Science, vol. 292, no. 5525, pp. 2337–2340, 2001.
- M. Spolidoro, L. Baroncelli, E. Putignano, J. F. Maya-Vetencourt, A. Viegi, and L. Maffei, “Food restriction enhances visual cortex plasticity in adulthood,” Nature Communications, vol. 2, no. 1, article 320, 2011.
- K. P. Kinzig, S. L. Hargrave, and E. E. Tao, “Central and peripheral effects of chronic food restriction and weight restoration in the rat,” American Journal of Physiology, vol. 296, no. 2, pp. E282–E290, 2009.
- A. V. Witte, M. Fobker, R. Gellner, S. Knecht, and A. Flöel, “Caloric restriction improves memory in elderly humans,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 4, pp. 1255–1260, 2009.
- G. J. Paz-Filho, T. Babikian, R. Asarnow et al., “Leptin replacement improves cognitive development,” PLoS ONE, vol. 3, no. 8, Article ID e3098, 2008.
- X.-L. Li, S. Aou, Y. Oomura, N. Hori, K. Fukunaga, and T. Hori, “Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents,” Neuroscience, vol. 113, no. 3, pp. 607–615, 2002.
- J. C. Garza, M. Guo, W. Zhang, and X.-Y. Lu, “Leptin increases adult hippocampal neurogenesis in vivo and in vitro,” The Journal of Biological Chemistry, vol. 283, no. 26, pp. 18238–18247, 2008.
- M. Caleo and L. Maffei, “Neurotrophins and plasticity in the visual cortex,” Neuroscientist, vol. 8, no. 1, pp. 52–61, 2002.
- K. K. Cowansage, J. E. Ledoux, and M.-H. Monfils, “Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity,” Current Molecular Pharmacology, vol. 3, no. 1, pp. 12–29, 2010.