Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication

Figure 2

BDNF mRNA expression (a) and protein level (b) in the dentate gyrus of the hippocampus (DG) or total hippocampus, respectively, after 7-day treatment with the 5-HT₄ partial agonist RS67333 (1.5 mg/kg/day) (modified from [8]) and 7-day coadministration of the SSRI fluoxetine (5 mg/kg/day) and the 5-HT_2A antagonist ketanserin (0.1 mg/kg/day). *𝑃<0.05 versus vehicle. Modified from Pascual-Brazo et al., 2012 [8], and Pilar-Cuéllar et al., 2012 [83].

(a)

(b)