Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication
Figure 3
Antidepressant treatment increases basal cAMP in both rat and human. (a) Increase of basal cAMP levels in rat hippocampus, frontal cortex and striatum after chronic (14 days) antidepressant treatment with fluoxetine (10 mg/kg/day) and venlafaxine (40 mg/kg/day), and subchronic treatment (3 days) with the 5HT4 agonist RS67333 (1.5 mg/kg/day) and in postmortem frontal cortex samples from control, antidepressant free-depressed subjects (AD-free MD) and antidepressant-treated depressed subjects (AD-treated MD). cAMP is expressed in pmoles/mg protein. *; ** and *** versus vehicle or control subjects; ●● versus antidepressant-free depressed subjects. (b) Modulation of receptor subtype-mediated inhibition of cAMP accumulation by antidepressant drugs. Chronic antidepressant treatment with fluoxetine (10 mg/kg/day) and venlafaxine (40 mg/kg/day) for 14 days downregulates 8-OH-DPAT inhibition of forskolin-induced cAMP accumulation. (a) Modified from Mostany et al., 2008 [10], Pascual-Brazo et al., 2012 [8], and unpublished results and (b) unpublished results.
