Review Article
Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication
Table 1
Role of the activation and blockade of the different serotonin receptor subtypes in neural proliferation and synaptic plasticity.
| | Serotonin receptor subtypes | Effect of pharmacological manipulation on hippocampal proliferation | ko | | Agonist | Antagonist | | | | Change | Reference | Change | Reference | Change | Reference |
| | 5-HT1A | proliferation (subchronic) |
[77] | proliferation (acute) | [78] | = proliferation |
[9, 71] | | = proliferation (chronic) | [79] | | proliferation (chronic) | [74, 79, 80] | blocks 5-HT-induced proliferation | [78] | cell survival | [9] |
| | 5-HT2A/2C | = proliferation (+SSRI) |
[74] | proliferation (chronic) | [81, 82] | No data | | | proliferation (acute) | [74, 81] | | | ↑ plasticity markers and BDNF (+SSRI, subchronic) | [83] | |
| | 5-HT4 | proliferation (subchronic) | [8, 64] | Blocks 5-HT-induced proliferation |
[78] | No data | | | plasticity markers and BDNF (subchronic) | [8, 63–65] | |
| | 5-HT6 | No data | | proliferation | [84] | No data | | | | plasticity markers (PSA-NCAM) | [84] | |
| | 5-HT7 | No data | | proliferation (subchronic) | [85] | = proliferation | [86] |
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: increase; : decrease; ko: knock-out mice.
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