Trains of Epidural DC Stimulation of the Cerebellum Tune Corticomotor Excitability
Figure 1
Examples of recruitment curves of corticomotor evoked responses (MEP: motor evoked responses) following incremental electrical stimulation of the right motor cortex for one rat. Recordings in left gastrocnemius muscle. (a) Recordings at baseline. (b) Recordings following application of anodal direct current stimulation over left cerebellar hemisphere. (c) Recordings following stimulation of left cerebellar hemisphere with cathodal direct current stimulation. (d) Superimposition of the 3 recruitment curves. Individual values are shown with red circles in (a), blue triangles in (b), and green circles in (c). Sigmoidal fitting (3 parameters: ); 95% prediction bands (dash) and 95% confidence bands (dotted) are shown in (a), (b), and (c). In (d), the slope from the first to the sixth point is smaller following anodal stimulation: 0.94 as compared to 1.1 at baseline and 1.22 after cathodal stimulation. Stimulation intensity is increased by steps of 0.1 mAmp following determination of the motor threshold on each side. Amplitudes are expressed in mV.
