Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina

Figure 2

Changes in expression of NMDA receptor subunits of DBA/2J mice at various ages. (a) Representative immunoblots showing the changes of NR1, NR2A, p-NR2A^S1232, NR2B levels in DBA/2J and C57BL/6 mice at ages of 3, 6, 9, and 12 months. (b)–(e) Bar chart showing the average densitometric quantification of immunoreactive bands of NR1 (b), NR2A (c), p-NR2A^S1232/NR2A (d), and NR2B (e) in DBA/2J and C57BL/6 mice at ages of 3, 6, 9, and 12 months, respectively. ^∗𝑃<0.05, ^∗∗𝑃<0.01 and ^∗∗∗𝑃<0.001 versus 3-month-old C57BL/6 mice; ^##𝑃<0.01 and ^###𝑃<0.001 versus 3-month-old DBA/2J; ^&&&𝑃<0.001 versus age-matched C57BL/6 mice.

(a)

(b)

(c)

(d)

(e)