The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA-NCAM within the Hippocampus

Table 2

Selected publications delineating the role of PSA-NCAM in adult hippocampal neurogenesis.

Authors	Species	Role in neurogenesis	Ablation method	Findings
McCall et al. 2013 [97]	Rat	Neurite outgrowth; survival	EndoN	Cleavage of PSA-NCAM caused expanded dendritic arborization and increased cell death
Burgess et al. 2008 [10]	Rat	Migration; differentiation	EndoN	Cleavage of PSA-NCAM disrupts normal migration and differentiation of newly generated neurons in the DG
Seri et al. 2004 [99]	?	Differentiation	—	PSA-NCAM is highly expressed in the entire cell body and growing processes of D cells (precursors in the generation of new granule neurons in the dentate gyrus)
Ni Dhuill et al. 1999 [100]	Human	Proliferation; neurite outgrowth	—	Hippocampal expression of PSA-NCAM throughout life in humans closely resembles that of the rat. Expression largely contained to granule cells of the dentate gyrus and their mossy fiber axons, with large reductions in expression with age
Seki and Rutishauser 1998 [98]	Mouse	Neurite outgrowth	NCAM KO; EndoN	Aberrant collateral sprouting of mossy fibers and ectopic synaptic bouton formation
Kuhn et al. 1996 [101]	Rat	Migration	—	Age related decline in PSA-NCAM expression in the GCL, reduced migration of PSA-NCAM expressing cells into the GCL
Fox et al. 1995 [102]	Rat	Proliferation	—	PSA-NCAM expression decreases with age, coinciding with decreased cell proliferation
Seki and Arai 1993 [103]	Rat	Proliferation; migration; differentiation	—	Newly generated granule cells in the dentate gyrus express a highly polysialylated form of NCAM, involved in the migration of immature neurons from the subgranular zone into the GCL
Seki and Arai 1991 [104]	Rat	Proliferation	—	Highly polysialylated form of NCAM is persistently expressed in the adult dentate gyrus

EndoN: endoneuraminidase N; GCL: granule cell layer.