The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA-NCAM within the Hippocampus

Table 3

Effects of stress and depression on the expression of PSA-NCAM.

(a) Animal models of stress and depression

Reference	Species	Sex	Model	Antidepressant	Effect on PSA-NCAM
Gilabert-Juan et al. 2012 [110]	Mouse	M	Chronic restraint stress	—	↔ in mPFC
Djordjevic et al. 2012 [111]	Rat	M	Chronic social isolation	—	↑ in HPC; ↓ PFC
Djordjevic et al. 2012 [109]	Rat	M	Chronic social isolation	Fluoxetine	↑ in HPC, ↓ by Flx treatment
Djordjevic et al. 2012 [112]	Rat	M	Chronic social isolation	Fluoxetine	↑ in PFC; ↓ by Flx treatment (with stress)
Gilabert-Juan et al. 2011 [113]	Mouse	M	Chronic restraint stress	—	↓ in CeM; ↔ in BLA; ↔ Me
Wainwright et al. 2011 [11]	Rat	M	Unpredictable chronic mild stress	—	↓ in HPC
Homberg et al. 2011 [116]	Rat	M	—	Fluoxetine	↓ in dRN; ↔ in mPFC; ↑ AMYG (adolescent), ↓ AMYG (adult)
Varea et al. 2007 [117]	Rat	M	—	Fluoxetine	↑ in HPC (str. luc. only); ↓ in Me and BMA; ↔ in BLA
Sairanen et al. 2007 [118]	Rat	M	—	Imipramine	↑ in HPC; ↑ plPFC
Varea et al. 2007 [119]	Rat	M	—	Fluoxetine	↑ in mPFC (whole); ↑ ilPFC; ↔ plPFC
Cordero et al. 2005 [105]	Rat	M	Chronic restraint stress	—	↓ in CeM; ↓ Me
Nacher et al. 2004 [66]	Rat	M	Oral corticosterone administration	—	↓ in HPC
Nacher et al. 2004 [106]	Rat	M	Chronic restraint stress; oral corticosterone administration	—	↓ in piriform cortex (oral CORT); ↑ in piriform cortex (restraint)
Pham et al. 2003 [107]	Rat	M	Chronic restraint stress	—	↑ in HPC (3 weeks), ↔ in HPC (6 weeks)
Sandi et al. 2001 [108]	Rat	M	Chronic restraint stress	—	↑ in HPC

(b) Human studies of depression

Reference	Subjects	Sex	Population assessed	Antidepressant	Effect on PSA-NCAM
Maheu et al. 2013 [114]	Human	?	Depressed patients postmortem	Specific classes not disclosed	↓ in BLA
Gilabert-Juan et al. 2012 [115]	Human	M and F	Depressed patients postmortem	Specific classes not disclosed	↔ in dlPFC
Varea et al. 2012 [2]	Human	M and F	Depressed patients postmortem	Specific classes not disclosed	↓ in BLA; ↓ in BMA

Me: medial amygdala; CeM: centromedial amygdala; BMA: basomedial amygdala; dRN: dorsal raphe nucleus; str. luc.: stratum lucidum; plPFC: prelimbic cortex; ilPFC: infralimbic prefrontal cortex; HPC: hippocampus; AMYG: amygdala; mPFC: medial prefrontal cortex.