Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons
Figure 1
Glutamatergic sEPSCs recorded from acutely isolated PAG neurons. (a) A typical trace of glutamatergic sEPSCs observed before, during, and after application of 20 μM CNQX, an AMPA/KA receptor blocker, at a V H of 0 mV in the presence of 10 μM SR95531 and 50 μM APV, selective GABAA, and NMDA receptor antagonists, respectively. Insets represent typical traces with an expanded time scale. (b) (A) Typical traces of glutamatergic sEPSCs at various holding potentials (). (B) A plot of the mean amplitude of sEPSCs at various values. The reversal potential was −2.5 mV, which is close to the theoretical equilibrium potential of monovalent cations. Each point was the mean and SEM from the 4 neurons.
