Review Article

Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

Figure 1

Astrocyte-secreted matricellular proteins: Developmental tools for reactivity purposes. Astrocyte-secreted matricellular proteins are highly expressed during the development of the CNS where they have multiple complex roles (left panel). In general, the expression of these molecules in the adult nervous system is reduced, but they are reexpressed at a high level in reactive astrocytes following injury or in disease states. Here, we summarise the possible roles of matricellular proteins secreted from reactive astrocytes (right panel).
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