Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Figure 2

Effect of the NO scavengers on SNP-induced membrane potential changes. SNP (1 mM)-induced hyperpolarization was decreased by pretreatment with Hb (a) and c-PTIO (c). Hb (b) and c-PTIO (d) decreased SNP (10 μM)-induced depolarization. (e) Pretreatment with PBN inhibited SNP (1 mM)-induced hyperpolarization. (f) PBN reduced SNP (10 μM)-induced depolarization. (g) Summary of data obtained under the control condition of SNP-induced responses and pretreatment with Hb, c-PTIO, and PBN. *Values are significantly different from the control (SNP), based on independent 𝑡-test analysis (𝑃<0.05), **𝑃<0.01, ***𝑃<0.001. Mean ± SEM.

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