Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Figure 4

Soluble guanylyl cyclase is involved in the SNP-induced responses. (a) SNP (1 mM)-induced membrane hyperpolarization in SG neurons was blocked by ODQ (40 μM). (b) Membrane depolarization by SNP (10 μM) was inhibited by pretreated with ODQ. (c) Summary data obtained under the control condition of 1 mM SNP-induced hyperpolarization and pretreatment with ODQ. (d) Summary data obtained under the control condition of 10 μM SNP-induced depolarization and pretreatment with ODQ. **Values are significantly different from the control (SNP), based on independent 𝑡-test analysis (𝑃<0.01), ***𝑃<0.001. Mean ± SEM.

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