Research Article

Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Figure 5

Effect of NEM, a thiol-modifying agent, on SNP-induced membrane potential changes. (a) Membrane hyperpolarization, induced by SNP (1 mM), was decreased by the presence of NEM. (b) SNP (10 μM)-induced depolarization was decreased by the application of NEM. (c) Summary of data obtained under the control condition of SNP-induced hyperpolarization and pretreatment with NEM. (d) Summary of data obtained under the control condition of SNP-induced depolarization and pretreatment with NEM. *Values are significantly different from the control (SNP), based on independent -test analysis ( ). Mean ± SEM.
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