Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia
Figure 4
MCM2-positive cell numbers in the total HC and different hippocampal subregions. (a) The total number of MCM2-positive cells in the HC was significantly higher in iLBD cases compared to control subjects (; nonparametric Mann-Whitney test). (b–f) Comparing MCM2 IR per HC subregion between the 3 different groups revealed a significant increase in number of proliferating cells in hippocampal areas (d) CA3 and (e) CA4 (resp., , ; nonparametric Mann-Whitney test) of iLBD cases versus control subjects. Significance reached at alpha of , Bonferroni-corrected. Data represent mean ± SEM.
