Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia

Figure 6

Colocalization of the majority of MCM2-positive cells with Iba1 in the hippocampal DG region of control subjects, iLBD cases, and PD patients. (a–f) Representative confocal laser scanning microscopical images of double-immunofluorescent stained sections revealed that the majority of the MCM2-positive cells show colocalization with the microglial marker Iba1 (arrows in (c), (f), and (i)). (b, d) Control subject shows one MCM2-positive cell with no colocalization with Iba1 (arrowhead). Iba1-positive microglia are depicted in green (a, d, and g) and MCM2 in red (b, e, and h); bar (a–i) = 40 μm.

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